We rented the penthouse apartment. The are is super centric, really well located, quiet, good to rest. The only problem is, it is NOT on Plaza Santa Ana, nor next to Río Darro, but it is pretty close.
My guess is they rent Río Darro and Apartamento Hospital de Peregrinos (Calle Hospital de Peregrinos #4) under the same Hotels.com listing. We didn't find out about this until we contacted them the day before our arrival to coordinate the checkin.
To be honest, our stay was perfect, I just didn't like, good value for what it costs, it's just, I didn't like not beeing sinces the beginning about the address change